Stepwise investment plan optimization for large scale and multi-zonal transmission system expansion

This paper develops a long term transmission expansion optimization methodology taking the probabilistic nature of generation and demand, spatial aspects of transmission investments and different technologies into account. The developed methodology delivers a stepwise investment plan to achieve the optimal grid expansion for additional transmission capacity between different zones. In this paper, the optimization methodology is applied to the Spanish and French transmission systems for long term optimization of investments in interconnection capacity

Auction-Based Allocation of Shared Electricity Storage Resources through Physical Storage Rights

This article proposes a new electricity storage business model based on multiple simultaneously considered revenue streams, which can be attributed to different market activities and players. These players thus share electricity storage resources and compete to obtain the right to use them in a dynamic allocation mechanism. It is based on the design of anew periodically organized auction to allocate shared storage resources through physical storage rights between different market players and ac-companying applications. Through such a flexibility platform owners of flexible resources can commercialize their flexible capacity over different applications, while market players looking for additional flexibility can obtain this through a pay-per-use principle and thus not having to make long-term investment commitments. As such, they can quickly adapt their portfolio according to the market situation. Alternatively, through such an allocation mechanism players can effectively share storage re-sources. Players may be incentivized to participate as they can share the investment cost, mitigate risk, exploit economies of scale, overcome regulatory barriers, and merge time-varying and player-dependent flexibility needs. The mechanism allocates the limited storage resources to the most valuable application for each market-clearing, based on the competing players' willingness-to-pay. An illustrative case study is provided in which three players share storage resources that are allocated through a daily auction with hourly market-clearings

Integrating short-term demand response into long-term investment planning

Planning models have been used for many years to optimize generation investments in electric power systems. More recently, these models have been extended in order to treat demand-side management on an equal footing. This paper stresses the importance of integrating short-term demand response to time-varying prices into those investment models. Three different methodologies are suggested to integrate short-term responsiveness into a long-term model assuming that consumer response can be modelled using price-elastic demand and that generators behave competitively. First, numerical results show that considering operational constraints in an investment model results in less inflexible base load capacity and more mid-range capacity that has higher ramp rates. Then, own-price and cross-price elasticities are included in order to incorporate consumers’ willingness to adjust the demand profile in response to price changes. Whereas own-price elasticities account for immediate response to price signals, cross-price elasticities account for shifting loads to other periods. As energy efficiency programs sponsored by governments or utilities also influence the load profile, the interaction of energy efficiency expenditures and demand response is also modelled. In particular, reduced responsiveness to prices can be a side effect when consumers have become more energy efficient. Comparison of model results for a single year optimization with and without demand response shows the peak reduction and valley filling effects of response to real-time prices for an illustrative example with a large amount of wind power injections. Additionally, increasing demand elasticity increases the optimal amount of installed wind power capacity. This suggests that demand-side management can result in environmental benefits not only through reducing energy use, but also by facilitating integration of renewable energy

Long term investment optimization methodology for multi-zonal transmission expansion

This paper introduces a stepwise investment optimization methodology for transmission system expansion planning. The objective of the developed methodology is to determine transmission expansion plans to realize a desired interconnection capacity between multiple zones minimizing investment and operational costs. The methodology uses MILP optimization and a modified A∗ shortest path algorithm sequentially in order to determine the optimal investment time point, transmission topology, technology and routing. Spatial constraints and their effects on the installation cost are taken into account in the technology and route optimization. A possible application of the methodology is demonstrated on a stepwise investment plan for the North Sea region

A Comprehensive Model of a Doubly Fed Induction Generator for Dynamic Simulations and

Abstract. The doubly fed induction generator (DFIG) is a very suitable generator type for wind turbine applications. However, its operation principles and its control are rather complex. This paper will describe the different steps for modelling and simulating the generator behaviour. A simulation example of the operation of a DFIG in a small power system is presented

Airway deposition of extrafine inhaled triple therapy in patients with copd: A model approach based on functional respiratory imaging computer simulations

Introduction: There is a clear correlation between small airways dysfunction and poor clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), and it is therefore important that inhalation therapy (both bronchodilator and anti-inflammatory) can deposit in the small airways. Two single-inhaler triple therapy (SITT) combinations are currently approved for the maintenance treatment of COPD: extrafine formulation beclomethasone dipropionate/formoterol fumarate/glycopyrronium bromide (BDP/FF/GB), and nonextrafine formulation fluticasone furoate/vilanterol/umeclidinium (FluF/VI/UMEC). This study evaluated the lung deposition of the inhaled corticosteroid (ICS), long-acting β2-agonist (LABA), and long-acting muscarinic antagonist (LAMA) components of these two SITTs. Materials and Methods: Lung deposition was estimated in-silico using functional respiratory imaging, a validated technique that uses aerosol delivery performance profiles, patients’ high-resolution computed tomography (HRCT) lung scans, and patient-derived inhalation profiles to simulate aerosol lung deposition. Results: HRCT scan data from 20 patients with COPD were included in these analyses, who had post-bronchodilator forced expiratory volume in 1 second (FEV1) ranging from 19.3% to 66.0% predicted. For intrathoracic deposition (as a percentage of the emitted dose), deposition of the ICS component was higher from BDP/FF/GB than FluF/VI/UMEC; the two triple therapies had similar performance for both the LABA component and the LAMA component. Peripheral deposition of all three components was higher with BDP/FF/GB than FluF/ VI/UMEC. Furthermore, the ratios of central to peripheral deposition for all three components of BDP/FF/GB were <1, indicating greater peripheral than central deposition (0.48 ±0.13, 0.48±0.13 and 0.49±0.13 for BDP, FF and GB, respectively; 1.96±0.84, 0.97±0.34 and 1.20±0.48 for FluF, VI and UMEC, respectively). Conclusions: Peripheral (small airways) deposition of all three components (ICS, LABA, and LAMA) was higher from BDP/FF/GB than from FluF/VI/UMEC, based on profiles from patients with moderate to very severe COPD. This is consistent with the extrafine formulation of BDP/FF/GB

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth

Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia during tumor progression are poorly understood. Using longitudinal intravital imaging in a mouse glioma model, we identify that dynamic sprouting and functional morphogenesis of a highly branched vessel network characterize the initial tumor growth, dramatically changing to vessel expansion, leakage, and loss of branching complexity in the later stages. This vascular phenotype transition was accompanied by recruitment of predominantly pro-inflammatory M1-like macrophages in the early stages, followed by in situ repolarization to M2-like macrophages, which produced VEGF-A and relocate to perivascular areas. A similar enrichment and perivascular accumulation of M2 versus M1 macrophages correlated with vessel dilation and malignancy in human glioma samples of different WHO malignancy grade. Targeting macrophages using anti-CSF1 treatment restored normal blood vessel patterning and function. Combination treatment with chemotherapy showed survival benefit, suggesting that targeting macrophages as the key driver of blood vessel dysmorphia in glioma progression presents opportunities to improve efficacy of chemotherapeutic agents. We propose that vessel dysfunction is not simply a general feature of tumor vessel formation, but rather an emergent property resulting from a dynamic and functional reorganization of the tumor stroma and its angiogenic influences